
Physiological and pharmacological experiments have suggested thatstevioside from the leaves of Stevia rebaudiana acts as a typical systemic vasodilator.CELL CULTUREResearchers found that stevioside (from Steviarebaudiana leaves) mediated vasorelexation effect through Ca(2+)influx inhibition.
Drinking of 0.1% stevioside (from Stevia rebaudiana) solutionin mature spontaneously hypertensive ratscould have antihypertensive (bloodpressure lowering) effect and also prevented hypertension (high blood pressure) in immature spontaneously hypertensive rats. Stevioside (from Stevia rebaudiana leaves) caused vasorelaxation via an inhibition of Ca(2+) influx into the blood vessel in a study of normal rats.
HUMAN demonstrated the antihypertensive (blood pressure lowering) effect of stevioside (from Stevia rebaudiana leaves) in a 3-month, multi-center, randomized, double-blinded, placebo-controlled study . A 2-year study of 168 patients suffered from hypertension (aged 20-75) demonstrated that oral stevioside (from Stevia rebaudiana Bertoni) decreased systolic and diastolic blood pressurewithout significant adverse effects.

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